Keywords

Actin Cytoskeleton; Adaptive Immunity; Individualized Medicine

Research interests

EXAMPLE:

I am a pediatrician with a focus on immunology and oncology. I was always fascinated by the fact that the immune system has to maintain a tightly regulated balance of complex pro- and anti-inflammatory responses, and tiny alterations of single genes tip the scales towards immunodeficiency, autoimmunity or cancer. My main research focus is to understand the importance of individual errors in human lymphocytes for disease development. The research is designed to elucidate sometimes common molecular mechanisms underlying immunodeficiency, autoimmunity and cancer. With this understanding we develop novel individualized herapeutic approaches. 

Techniques, methods & infrastructure

EXAMPLE:

 Exome sequencing, single cell RNA sequencing (10x), Immunofluorescence microscopy, live-cell imaging, DNA and protein editing technologies (CRISPR-Cas9, targeted protein degradation), flow cytometry

Selected publications

1. Salzer, E. et al., 2020. The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity. Science Immunology, 5(49), p.eabc3979. Available at: http://dx.doi.org/10.1126/sciimmunol.abc3979.
2. Ghosh, S. et al., 2020. Extended clinical and immunological phenotype and transplant outcome in CD27 and CD70 deficiency. Blood, 136(23), pp.2638–2655. Available at: http://dx.doi.org/10.1182/blood.2020006738.
3. Salzer, E. et al., 2016. RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics. Nature Immunology, 17(12), pp.1352–1360. Available at: http://dx.doi.org/10.1038/ni.3575.
4. Salzer, E. et al., 2014. Early-onset inflammatory bowel disease and common variable immunodeficiency–like disease caused by IL-21 deficiency. Journal of Allergy and Clinical Immunology, 133(6), pp.1651–1659.e12. Available at: http://dx.doi.org/10.1016/j.jaci.2014.02.034.
5. Salzer, E. et al., 2013. B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C δ. Blood, 121(16), pp.3112–3116. Available at: http://dx.doi.org/10.1182/blood-2012-10-460741.